Hi all,
I have raw MS data with noisy background matrix (may due to column bleed or contamination with various m/z values) that keep showing in the real sample, BF. Is there any way to subtract all ions matrix from blank sample from sample matrix?
Kindly refer to my previous query regarding this issue in the link below :
https://www.researchgate.net/post/How_to_subtract_noise_molecular_ion_column_bleed_contamination_from_mass_spectrum_using_Mzmine_OpenChrome2
Thanks!
The "noisy background" you obtained was due to the use of a poor quality HPLC method (as described previously). Instead of worrying about removing noise obtained from a poor quality method, please go back and develop a sound method which is appropriate for your sample(s). Trying to "turn" poor quality data into scientific data is not the answer. Please get some local help to develop a better quality method. This will solve your problem.
BTW: Subtracting "blank" runs from "sample" runs is a standard feature built-into most manufacturer's MS software products. Anyone trained to use the software should be able to easily help you with this request.
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