I have a method for Microsphere preparation detailed as-
Kindly suggest the substitution for Corn Oil in below method.
Preparation of Microspheres by Thermal cross-linking
Citric acid, as a cross-linking agent was added to 30 ml of an aqueous acetic acid solution of chitosan (2.5% wt/vol) maintaining a constant molar ratio between chitosan and citric acid (6.90 × 10-3 mol chitosan: 1 mol citric acid). The chitosan cross-linker solution was cooled to 0°C and then added to 25 mL of corn oil 2 minutes. This emulsion was then added to 175 mL of corn oil maintained at 120°C, and cross-linking was performed in a glass beaker. Under vigorous stirring (1000 rpm) for 40 minutes. The microspheres obtained were filtered and then washed with diethyl ether, dried, and sieved.
Since you're talking about an acid catalysed polymerization of the unsaturated alkyl chains of an oil, and corn oil is about 85% mono- and poly-unsaturated (in terms of its fatty acid composition), soy oil should replace adequately, among many others. Check if you're using un-GMO or GMO (high SDA, at the expense of linoleic acid) soy oil; the latter may cross-link more aggressively.
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