We live in a rapidly changing global competitive environment where new knowledge is created, disseminated, and commercialized to provide innovative products and services. In this global competitive environment where the rapid developments are experienced in the fields of science and technology, countries must increase their ability to produce new knowledge and to commercialize it by converting new technologies to take quick and competitive steps. In contrast to most researches conducted in the private sector, the main purpose of researches carried out in universities is to produce new academic knowledge. For this reason, universities are the primary source of new knowledge production.Therefore, University spin-off companies are an important agency for dissemination and commercialization of new knowledge. What about innovative start-ups? Are they important agencies for dissemination and commercialization of new knowledge like university spin-offs? Or they are really different?