Congratulations, you discussed a very interesting issue. I agree with the individualized therapeutic approach, especially in the patients with mild haemophilia phenotype. I would like to discuss the management of elderly haemophilia patients with atherosclerosis, obesity, smokers who have undergone an episode of arterial thrombosis. What do you think about the combination of replacement and antiplatelet therapy? How many haemophilic patients with diabetes and other conditions such as cancer do you have?
Article Rationale for individualizing haemophilia care
Dear Peter, your question is quite interesting and valid. I wanted to read the paper but didnt have access to it. Do you have access to the full text of the article?
There is increasing interest in hemophilia and aging, as this population is living a normal lifespan and facing comorbid conditions related to aging, such as those you mention Dr. Kubisz. May I recommend just a few publications, including the first one which is from my institution. If you have an interest in a more comprehensive bibliography, please let me know. Kind regards, Natalie Duncan, MPH
Dear Peter, there is a brief article about older hemophilia pts in Poland.
Kind regards,
Krystyna
Dear Peter Kubisz,
Here are some publications on haemophilia and ageing:
- Canaro M, Goranova-Marinova V, Berntorp E. (2015). The ageing patient with haemophilia. Eur J Haematol. 94 Suppl 77:17-22.
- Franchini M, Tagliaferri A, Mannucci PM. (2007). The management of hemophilia in elderly patients. Clin Interv Aging. 2(3):361-8.
- Miesbach W, Schelle G, Kalnins W. (2013). [Life with haemophilia. The patient's perspective of ageing]. Hamostaseologie. 33 Suppl 1:S22-4. German.
- Smith N, Bartholomew C, Jackson S. (2014). Issues in the ageing individual with haemophilia and other inherited bleeding disorders: understanding and responding to the patients' perspective. Haemophilia. 20(1):e1-6.
- Street A, Hill K, Sussex B, Warner M, Scully MF. (2006). Haemophilia and ageing. Haemophilia. 12 Suppl 3:8-12.
- Zawilska K, Podolak-Dawidziak M. (2012). Therapeutic problems in elderly patients with hemophilia. Pol Arch Med Wewn. 122(11):567-76.
- Zimmermann R, Staritz P, Huth-Kühne A. (2014). Challenges in treating elderly patients with haemophilia: a focus on cardiology. Thromb Res. 134 Suppl 1:S48-52.
A Pubmed search using the search strategy [haemophilia AND (elderly[TITLE] OR ageing[TITLE]] yields 56 results.
I'm new in the field of haemophilia so I can not contribute to the discussion. But I wish you good luck for yoir work.
Dear Peter,
an expert in your field of interest would be Dr. Wolfgang Miesbach, head of the hemophilia clinic at the university clinics of the Goethe University in Frankfurt/Main, Germany.
If you can send an email directly to [email protected], I will send you his mail address.
Best,
Markus