I could not found any evidence. But as per our clinical experience, there is no significant difference in both gels

Dear Ajai,

Good day to you and thank you for your response. Are there any papers I can look at that you know of concerning the above topic? Thank you very much

Arvinder

Dear Arvinder

This article may be useful for you

1) Moore RA, Tramer MR, Carrol D, et al. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 1998;316 :333– 338

Dear Arvinder, There are several published studies on this topic. Clinical trials of most NSAIDs demonstrate a higher efficacy of topical ketoprofen compared to placebo, but similar to oral NSAIDs for people with mild to moderate OA of the knee or hand (1). Unfortunately, there is no clear statement in support or unsupport for kepoprofen gel versus ultrasound. A recent study by Rother goes in favor of ketoprofen-free vehicle (TDT 064) rather than ketoprofen gel (IDEA-033) in moderate OA (2). Another group from Turkey could not find a clinically relevant difference amongst ketoprofen phonophoresis, ultrasound, and short-wave diathermy in knee osteoarthritis (3). Let me know if you find otherwise. Hope this helps! Amit

Papers:

1. Altman RD, Barthel HR. Topical therapies for osteoarthritis. Drugs. 2011;71 (10): 1259-79. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/21770475

2. Rother M, Conaghan PG. A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. J. Rheumatol. 2013;40 (10): 1742-8. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/23996292

3. Boyaci A, Tutoglu A, Boyaci N et-al. Comparison of the efficacy of ketoprofen phonophoresis, ultrasound, and short-wave diathermy in knee osteoarthritis. Rheumatol. Int. 2013;33 (11): 2811-8. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/23832291

Dear Nelson and Amit,

Good day to you and thank you for your responses. Much appreciated.

Arvinder