Is there any chemical/compound which can be used as an inhibitor for Homoserine lactone production (Signalling molecules in bacteria)?

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Paweł Krzyżek

There are also various synthetic-plant derived substances with anti-quorum sensing activity, e.g. vanillin or cinnamaldehyde.

Article Inhibition of Quorum Sensing Mechanism and Aeromonas hydroph...

Article Cinnamaldehyde and cinnamaldehyde derivative reduce virulenc...

Article Subinhibitory concentrations of Cinnamaldehyde interfere wit...

Maurice Ekpenyong

Halogenated furanones are irreversible quorum sensing inhibitors that induce degradation of the LasR receptor protein can inhibit Quorum sensing very effectively. 5-imino-4,6-dihydro-3H-1,2,3-triazolo[5,4-d]pyrimidin-7-one, bismuth porphyrin complexes, glycosylation reagents of glycosylated flavonoids are other options. For details, see the attached documents. Good luck!

Vinothkannan Ravichandran

https://www.nature.com/articles/srep16569

Erandapurathukadumana Sreedharan Hareesh

Thanks Ravichandran