Halogenated furanones are irreversible quorum sensing inhibitors that induce degradation of the LasR receptor protein can inhibit Quorum sensing very effectively. 5-imino-4,6-dihydro-3H-1,2,3-triazolo[5,4-d]pyrimidin-7-one, bismuth porphyrin complexes, glycosylation reagents of glycosylated flavonoids are other options. For details, see the attached documents. Good luck!