Just few more clinical considerations about the results coming from this study: those patients with poor treatment adherence and higher rates of lifetime abuse of benzodiazepines may both be at increased risk for withdrawal symptoms and BDZ dependence and increased risk for depressive recurrence, which may on turn depend upon the prolonged use of high doses of BDZs themselves.
Also, the the lifetime addiction towards opiates pain-killers available over the counter, including codeine, may result in chronic modulation of CB1 receptors via mu-receptors at the nucleus accumbens. While opiates may alleviate the acute perception of pain, they are also known to induce a sort of transient apathy, which though leading to tachyphylaxis, it is particularly "appreciated" by those acute depressed patients characterized by intense impulsivity and immediate need for therapeutic relief ("therapeutic sensation seeking").
Article Treatment adherence towards prescribed medications in bipola...
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