I have met a man who is taking 75mg of aspirin daily because his spouse read a study that this can help cutting the risk of cancer (by being anti-inflammatory). The side effects of bleeding and other possible complications came to my mind, but I have not done an extensive research on this topic so I don't know. He said that the dose is low and so far he had no problems. Any insight on that? Thanks.
Studies in animal models support the idea that reducing chronic inflammation decreases the risk of developing aging-associated diseases, including certain cancers. There is some evidence to support this idea in humans. Therefore, it is conceivable that taking aspirin on a daily basis could decrease chronic inflammation in certain individuals. However, as you stated, there could be side effects that depend on the dose of aspirin and individual genetic background. Because emerging evidence suggest that each individual may be different and could respond differently to aspirin (or other anti-inflammatory drugs), more studies are needed to be able to suggest that a daily dose of aspirin (or any other drug) can help cutting the risk of cancer in individuals.
NSAIDs in general show an antitumoral behavior, including aspirin, celecoxib, piroxicam, tolfenamic acid, sulindac as the most investigated.
Usually the mechanism of action is through COX2 inhibition, NF-kB downregulation and in certain cases like sulindac through STAT3 downregulation.
Regarding aspirin, there is hard evidence that shows that it acts against colon adenomas.
See https://www.nature.com/articles/nrclinonc.2011.199
Best regards
Based on basically anti-inflammatory pathways, there are some studies that shows significant survival benefit especially for metastatic breast cancer patients.
Article Low-dose aspirin use and survival in breast cancer patients:...
Article End-of-life prescribing of aspirin in patients with breast o...
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