i understand that autism/asperger and anxiety disorders are under the Reward Deficiency Syndrome umbrella as these share common neurobiological similarities..............there is some question as to whether Ehlers-Danlos Syndrome is associated in some way
"Is Ehlers-Danlos syndrome related to autism?
Studies show that people with joint hypermobility, Ehlers-Danlos syndromes (EDS), and hypermobility spectrum disorder (HSD) have a higher likelihood of being autistic than would be expected by chance"
https://www.ehlers-danlos.com/autism-acceptance-month/#:~:text=Studies%20show%20that%20people%20with,would%20be%20expected%20by%20chance.
"Does Ehlers-Danlos cause ADHD?
Moreover, in a population-based matched cohort study in Sweden (n = 1,771), individuals with EDS were 5.6 times (95% CI: 4.2–7.4) more likely to have an ADHD diagnosis than those without EDS. Both autism and ADHD are commonly associated with the expression of tics."
https://autism.org/researchers-have-identified-a-relationship-between-ehlers-danlos-syndrome-and-autism/
Article The Relationship between Autism and Ehlers-Danlos Syndromes/...
Hi,
Here are a few references :
Casanova EL, Baeza-Velasco C, Buchanan CB, Casanova MF. The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders. J Pers Med. 2020 Dec 1;10(4):260. doi: 10.3390/jpm10040260. PMID: 33271870; PMCID: PMC7711487.
Sieg KG. Autism and Ehlers-Danlos syndrome. J Am Acad Child Adolesc Psychiatry. 1992 Jan;31(1):173. doi: 10.1097/00004583-199201000-00034. PMID: 1537777.
Sinibaldi L, Ursini G, Castori M. Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers-Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised. Am J Med Genet C Semin Med Genet. 2015 Mar;169C(1):97-106. doi: 10.1002/ajmg.c.31430. PMID: 25821094.
Rocchetti M, Bassotti A, Corradi J, Damiani S, Pasta G, Annunziata S, Guerrieri V, Mosconi M, Gentilini D, Brondino N. Is the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers-Danlos Syndrome, an Internet-Based Survey in Italy. Healthcare (Basel). 2021 Oct 30;9(11):1472. doi: 10.3390/healthcare9111472. PMID: 34828519; PMCID: PMC8622087.
Baeza-Velasco C, Cohen D, Hamonet C, Vlamynck E, Diaz L, Cravero C, Cappe E, Guinchat V. Autism, Joint Hypermobility-Related Disorders and Pain. Front Psychiatry. 2018 Dec 7;9:656. doi: 10.3389/fpsyt.2018.00656. PMID: 30581396; PMCID: PMC6292952.
Takei A, Mera K, Sato Y, Haraoka Y. High-functioning autistic disorder with Ehlers-Danlos syndrome. Psychiatry Clin Neurosci. 2011 Oct;65(6):605-6. doi: 10.1111/j.1440-1819.2011.02262.x. PMID: 22003996.
Nisticò V, Iacono A, Goeta D, Tedesco R, Giordano B, Faggioli R, Priori A, Gambini O, Demartini B. Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary study. Front Psychiatry. 2022 Aug 24;13:943098. doi: 10.3389/fpsyt.2022.943098. PMID: 36090363; PMCID: PMC9450495.
The link between Ehlers-Danlos Syndrome (EDS) and Reward Deficiency Syndrome (RDS) is fascinating. While direct evidence is scarce, both conditions involve dopamine dysregulation, crucial for motivation. EDS, known for connective tissue issues, has recent studies hinting at dopaminergic system involvement, especially in symptoms like chronic pain. Exploring overlaps between EDS and RDS could uncover shared mechanisms, offering new treatment avenues.
- Badges
- Science topic
- Similar topics
- Psychology