After breast conservation angiosarcoma was diagnosed. 1 yr. later a recurrence of the thoracic wall occurred with additional R0 resection. Is adjuvant chemotherapy recommended ?
Dear Stefan,
If the size of angiosarcoma reaches 3cm, post-R-zero adjuvant chemotherapy is indicated. If the patient has undergone anthracycline based adjuvant chemotherapy before. Gemcitabine + docetaxel combination is recommended for up to 4 cycles. This is my personal recommendation.
Wish you all the best in treating this woman.
I guess that our main purpose in the treatment of an angiosarcoma is to reach the local control with a wide excision; what about a new operation and/or radiation therapy?
My recommendation is antiangiogenic therapy with cytotoxic drug. It can be treated with fewer side effects than using cytotoxic drug or drugs only. And also we can increase the choices of anticancer drug treatment (e.g. gemcitabine or docetaxel +combination of antiangiogenic drugs). I think the combination of thalidomide and celecoxib is the best choice for angiosarcoma.
http://hadaclinic.com/
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