I guess yes because calcium is required for many important metabolic processes in a cell and if tumour cells need to copy there number i.e proliferate they will require calcium for doing so.

Hi,

I agree with above answer. Altered calcium signaling in cancer cells affect many aspect of tumorigenesis including proliferation, angiogenesis, cell migration, invasion, metastasis and apoptosis evasion. Tumor microenvironment consists of neoplastic cells and stroma. Stroma is responsible to provide sufficient nutrients, O2 and signalling cascades to sustain tumor growth. Hypoxic condition and elevated pressure often found in tumors triggered many signalling cascades, some of them leads to influx of Calcium, which will promote tumor growth . Therefore, interactions between tumor and stromal cells are essentials to maintain tumor growth and expansion, mostly through Calcium-dependent signaling .

ECM increased calcium may be important, but it is not crucial for tumor progression.