Variants of SARS-CoV-2 with a widespread mutation are more infectious in human cells and hamsters, compared with viral variants lacking the change.In February 2020, researchers examining samples from people with COVID-19 detected a SARS-CoV-2 mutation that alters the amino acid sequence of the virus’s spike protein, which the virus uses to infect cells. The amino-acid alteration, known as D614G, became common in Europe, North America and elsewhere in spring 2020, and now nearly all viruses isolated worldwide carry the alteration.
To determine the effects of the D614G change, two independent teams engineered SARS-CoV-2 particles with the mutation. Pei-Yong Shi at the University of Texas Medical Branch in Galveston, Texas and his colleagues conducted one set of experiments Ralph Baric at the University of North Carolina-Chapel Hill and his colleagues conducted the other
Both teams found that, compared with forms of the virus that lack the mutation, D614G variants replicated more efficiently in cells from human airway tissues. Baric’s team also found that D614G variants spread faster between hamsters, which are used to study SARS-CoV-2 transmission. Neither finding has been peer reviewed yet.
https://www.biorxiv.org/content/10.1101/2020.09.01.278689v1
https://www.biorxiv.org/content/10.1101/2020.09.28.317685v1
Coronavirus Cases:
34.52 million
Deaths:
1.03 million
Recovered:
25.7 million
Please have a look at these useful RG links.
Research Tracking changes in SARS-CoV-2 Spike: evidence that D614G in...
Preprint The D614G mutation in the SARS-CoV-2 spike protein reduces S...
Please go through the attached article entitled, "SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor-binding domain"
Please have a look at these useful RG links.
Research Tracking changes in SARS-CoV-2 Spike: evidence that D614G in...
Preprint The D614G mutation in the SARS-CoV-2 spike protein reduces S...
Have a look at the following links:
https://www.nature.com/articles/d41586-020-02544-6
https://www.news-medical.net/news/20200904/D614G-spike-mutation-increases-infectivity-of-SARS-CoV-2-and-neutralization-susceptibility.aspx
https://www.news-medical.net/health/D614G-Mutation.aspx
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