Dear friends, I read an article recently published (Danielle M. Townsley, Bogdan Dumitriu, Delong Liu, Angélique Biancotto, Barbara Weinstein, Christina Chen, Nathan Hardy, Andrew D. Mihalek, Shilpa Lingala, Yun Ju Kim, Jianhua Yao, Elizabeth Jones, Bernadette R. Gochuico, Theo Heller, Colin O. Wu, Rodrigo T. Calado, Phillip Scheinberg, Neal S. Young. Danazol Treatment for Telomere Diseases. New England Journal of Medicine, 2016; 374 (20): 1922 DOI: 10.1056/NEJMoa1515319). It is hypothesized that androgen can increase Telomere length and indirect measure for lifespan, though, since long we know that females often live a longer life and demographic population data also reveal the same.
I am unable to understand the contradiction, do anyone can explain.
sir,
By the littile knowledge i m trying to explain......
First I would like to explain that not only androgen but several hormones are also involved in telomerase regulation/activation. The current studies revealed (2016) fact only for androgen, that androgen can increase Telomere length and indirect measure for lifespan, making previous studies more stronger which were conducted in 2000 i.e., (telomerase activity is reduced by androgen deprivation, while treatment with testosterone/androgen restores high levels of telomerase activity (Soda et al., 2000).
Besides this Estrogen is also playing a strong role in telomerase activity and directly or indirectly activates telomerase (Kyo et al., 1999).
Which one is playing more role in telomerase activity not studied well (lacking comprehensive studies). So it is very difficult to understand the contradiction of life span of women and men that whose role are better in longer life span.
plz share more information of telomere......
They said, "In our study, treatment with danazol led to telomere elongation in patients with telomere diseases." That does not mean telomere can be elongated in the normal population and thus may or may have something to do with the lifespan of the normal population.
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