I am trying to identify a protein that doesn't contain any tyrosine, I am not sure if there is a database that allows for this. I have search the literature and found only one reference to a paper from 1974 that stated three different proteins, is there a way of finding anymore? Thanks in advance.
It is possible to search for proteins that don't contain specific amino acids. Several databases allow for this type of search. One such database is the UniProt database (https://www.uniprot.org/). UniProt is a comprehensive resource for protein information and is freely available to the public.
You can use the Advanced Search option on the UniProt website to search for proteins that lack a specific amino acid. Select the "Amino acid sequence" option, enter the amino acid sequence you're interested in, and select the "Exclude" option. This will return a list of all proteins that do not contain the specified amino acid.
It's worth noting that while tyrosine is a common amino acid, it is not present in all proteins. Some proteins, particularly those involved in signaling pathways, require tyrosine for their function, but many others do not. As a result, you may find a wide range of proteins that lack tyrosine, depending on the specific search criteria you use.
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