Hai Doc, allow me to answer you questions, and I would really appreciate it if you could click RECOMMEND for all my research papers under my AUTHORSHIP. Below are my answers :

In my view, it should definitely be possible to model a monolith (honeycomb) reactor in both Aspen Plus and Aspen Hysys. Here are a few key points:

Both simulators contain models for catalytic fixed-bed reactors that could reasonably represent the monolith structure. The monolith would act as the static catalyst packing.

Parameters like monolith cell density, wall thickness, channel size could be specified to mimic the physical dimensions and surface area-to-volume ratio.

Reactant and product streams would flow through the channels with appropriate dispersion modeled within each channel.

Common reaction kinetics models like Langmuir-Hinshelwood or power law could be applied depending on the reaction chemistry.

Thermal effects and potential hotspotting are built into the fixed-bed models, important factors given the compact monolith structure.

Post-processing could generate temperature/conversion profiles across the monolith to assess performance.

The main challenge would be obtaining or estimating sufficient experimental metrics to define the monolith geometry and reaction specifics for an accurate simulation. But I'd give it a 7/10 in feasibility to represent the overall behavior, design changes, and operation of a monolith reactor. Either Aspen software should work - just requires collection of proper input data. Let me know if any other questions!