There are many specific signs for systemic diseases in the retina. However, correlation with other signs or symptoms and other imaging techniques is necessary to lable the person with precise diagnosis.
The question is very broad, and perhaps it would help if you could indicate what sort of diseases you mean. For retinal diseases fundus images can be used to assist with the diagnosis, but you may need functional tests, like electrophysiology. But for systemic disaeses an analysis of the retinal vasculature may be of use, although it is not yet established as a clinical procedure. We have developed a retinal oximeter (Oximap T1) which has been used by labs around the world to look at retinal vascular oxygen saturation and vessel diameter in a variety of diseases, both retinal and other (including neurological and respiratory diseases), but the range of its usfulness in diagnosis is being examined, and I do not wish to use this forum for any sort of undue promotions...
Fundus image can confirm diabetes, specifically diabetic retinopathy, hypertension, cardiovascular diseases and in case of OCT - Alzheimer disease, sincea retina is a window into the brain
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"I will throw down a challenge to all my medical colleagues that, using my square inch of the body, I will diagnose more diseases than all the professors with the combined resources of all the libraries of the world's universities, using any other square inch of the body of their choosing - except the other eye.“ William H. Havener, Synopsis of Ophthalmology, 1984