I normally use the Plackett Burman design to evaluate the importance of each component, but in this case, I'm using a mixture of substrates for solid-state fermentation and the amount of each of them influences the proportion of the others in the mixture. We've performed mixture experimental designs in these cases, but now we would need to use around eight factors. My question is; which design based on mixtures would allow us to use many factors in two levels in order to obtain a Pareto chart showing the importance of each factor? I think an adaptation of Plackett Burman for mixtures would be ideal, but I only find normal mixture designs with up to three ingredients. Any ideas?
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