You can find a great selection of research on tobacco and health related studies at the tobacco research unit at the University of Bristol. A list of publications can be found here:

http://info.uwe.ac.uk/search-results?q=tobacco

Continued use of nicotine as a raw material for the preparation of derivatives : In 1978, Itokawa investigated the methyl radical alkylation of nicotine and observed a mixture of products with racemization

Among problems that nicotine might solve.

Because of its numerous biological effects, nicotine has the potential to be used as a therapeutic agent as well as an insecticide.

- Use of nicotine as a therapeutic drug for various CNS diseases.

Recent studies have shown the beneficial effects following administration of nicotine on patients suffering from Parkinson’s disease, anxiety, schizophrenia, Alzheimer’s disease, uterative colitis and other CNS disorders.24 However, detrimental effects including actions on both the cardiovascular and gastrointestinal systems, sleep disturbance and dependence limit the use of nicotine as a therapeutic reagent. One of the contemporary challenges is to synthesize nicotine derivatives that would display the same beneficial effects of nicotine at lower toxicity .

Research interests :CHEMISTRY ON NICOTINE ,Substitution on the nicotine pyridine ring

The reactivity of nicotine towards bases was tested by Tschitschibabin and Kirssanov in 1924. They prepared 2- and 6- amino nicotines by using sodium or potassium amide .[1] However, this reaction resulted in racemization which they thought, occurred via the formation of a carbanion at C-2’ of the pyrrolidine ring. This hypothesis was proved to be wrong by Seeman who found the correct intermediates responsible for the racemization . [1] .Tschitschibabin, A. E.; Kirssanov, A. W. Chem. Ber. 1924, 57, 1163.

As was also done conversion of amino nicotines to chloro and hydroxyl nicotines.They converted the aminonicotines to chloronicotines using HCl, and to the hydroxynicotines via formation of a diazonium salt with nitrous acid

SYNTHESIS OF NICOTINE DERIVATIVES FROM

NATURAL NICOTINE :In 1970, Sulzbach reported the reductive disilylation of pyridine with alkali metals and trimethylsilyl chloride. 1,4-Bis(trimethylsilyl)-1,4-dihydropyridine was isolated in 34 %yield and was found to be extremely air sensitive; oxidation occurred on exposure to air to give 4-(trimethylsilyl)pyridine

[2] . Sulzbach, R. A. J. Organomet. Chem. 1970, 24, 307.

Nicotine

The organic chemistry of nicotine has been unexpectedly unexplored. Only one paper has investigated the synthesis of nicotine derivatives as potential chiral coordination ligands.

Earlier reports on syntheses of C-2, C-4 and C-5 substituted nicotine derivatives were accomplished by starting with an appropriate functional group already substituted on the pyridine ring. For example, racemic 4-methyl and 2-methylnicotine were synthesized starting from 4-methyl and 2-methylpyridine-3-carboxaldehyde .

Racemization of nicotine via pyrrolidine ring opening .In 1985, Seeman studied the addition of organolithium reagents to nicotine and observed the regiospecific formation of partially racemized 6-alkylnicotinoids

Some studies have shown that the rings are heterogeneous in C-4, C-5 and C-6 of the pyridine ring of nicotine and nicotine derivatives through the use of catalysts

Via the N-oxide.

Nicotine N-oxide was recently treated with 10 equivalents of phosphorus oxychloride to give a mixture of 2-chloro and 6-chloro nicotines in low yield[12]. Addition of 3.4 equivalents of diisopropylamine eliminated the formation of the 2-chloronicotine, yielding 38% of 6-chloronicotine . [12]-Schmidt, B.; Neitemeir, V. Synthesis 1998, 42-44.

Tobacco has long been used to treat headaches, colds and ulcers [16]. [16]. Mansk, R.H.F, .(1950). The alkaloids chemistry and physiology . vol . 1.

Academic press , New york . Ine . p. 1950-1955.

Plant Pesticides. Manufactured in a natural way mediated by living plants. Such as nicotine derived from leaves of tobacco plants, which use an effective insecticide against plant lice.

Tobacco (Nicotiana Tabacom)

Tobacco contains nicotine, which can be used as an effective insecticide. (Be careful, since nicotine is a poison, and high concentrations can be deadly). Target organisms include manna, cabworm, larvae, flea beetles, grain fluids, paper miners, mites, leg acid, ribs, rust, some fungus, virus curl. Note: Do not use on tomatoes, eggplant, pepper or potatoes.

Recipe: First, dry and pound leaves. Add 20 grams of tobacco to 1 liter of water, soak overnight, and apply during evening watering.

Development of Therapeutics: Research into nicotine chemistry can aid in the development of medications for nicotine dependence and potentially other conditions. Understanding nicotine's interactions with receptors in the brain can lead to the development of more targeted therapies.