I found contradictory sources.
Are patients suffering from glioblasoma treated with Paclitaxel.
Do they develop resistance to Paclitaxel over-time like it's the case with other cancers.
Thanks a lot.
Hi Pierre,
Patients with newly diagnosed glioblastoma are almost universally treated with surgery, to remove as much of the tumour as is safely possible, followed by radiotherapy and temozolomide chemotherapy (as per the Stupp regimen: Article Radiotherapy plus Concomitant and Adjuvant Temozolomide for ...
).More recently tumour treating fields (TTFields), a new modality which uses alternating electrical fields to interfere with mitotic spindles in dividing cancer cells, as been shown to further improve survival in patients with glioblastoma (Article Effect of Tumor-Treating Fields Plus Maintenance Temozolomid...
) when administered alongside the above Stupp regimen.Options for further treatment once glioblastoma recurs are more diverse, with no clear established standard - but I have never seen any patients with glioblastoma at our institution treated with paclitaxel and can't imagine that this would be common.
Nevertheless, there is some pre-clinical evidence of efficacy with paclitaxel, particularly when combined with TTFields - which seems rational given its MoA - so maybe one to watch for the future?
Dear Dr. Ola Rominiyi, many thanks for your incisive comments. Also for the references provided.
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