Not always, This depend on composition of the herbal and the nature of these contents, as for example when the plant contain three of substances one of them is benefit and the others are harmful, So the use isolated substance safer than crude.
you are touching at an interesting question: Herbal medicine versus pharmacologically produced substances. What are the principal differences? Safety is not the main question, of course good manufacturing given. The famous Swiss medieval doctor and philosopher Paracelsus (1493 -1541 AD) coined the famous Latin sentence: Dosis facit venenum. The dosage decides whether something is poison or not. The main difference between a plant and a chemical monosubstance is that the different components influence, sometimes even reinforce each other.The sum is more than a simple addition. If you prescribe different monosubstances In conventional medicine plus another pill to protect the stomach mucosa the compliance of the patient to swallow ten different tablets will be overloaded.
This is completely dependent on the individual constituents. In the raw herbs there is often some synergistic quality, which often makes more intense or possible dangerous compounds safer. Likewise the synergistic whole herb compounds may activate other constituents further. In Tibetan medicine, this is also why many herbs are combined and also dependent on the substance which may be dangerous singly, or in large amounts due to specific active compounds thus requiring prepared means, or having been purified in a special way singly or by adding to other herbs in a formula approach. This is also dependent on taste, which derive themselves from elements and are natures way of effecting change within the quantity of the plant. This is in sharp contrast to the modern pharmaceutical approach of isolated active principles.