Is contact maps analysis for the interaction between enzyme and ligand?

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Yun-Tzai Lee

Hi Maryam Mapar

I guess what the reviewer suggested is to compare the protein contact maps (https://en.wikipedia.org/wiki/Protein_contact_map) between ligand-free and bound structures. See there is any differences in between which may implicate some important structural rearrangements for enzymatic activity.

Maryam Mapar

Yun-Tzai Lee I think you are right. thank you for answer.