I am working on polylactic acid production from lactose. After production of lactic acid, is there any biological (microbes/bioenzymes) which can convert it to polylactic acid? Direct conversion of lactose to polylactic acid by microbes is also desirable.
No, first a dilactide has to be produced by heat and an acid and then the polymer with a catalyst.
Have a look at this paper:
Biotechnol Bioeng. 2010 Jan 1;105(1):161-71. doi: 10.1002/bit.22548.
Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers.
Jung YK1, Kim TY, Park SJ, Lee SY.
Thank you. But genetic modification is out of my scope right now, i want to know any natural microbes who are know to do so.
To the best of my knowledge there is a (direct) route of polycondensation (but limits in view of the final molecular weight) and/or as already mentioned by Marc the ring opening polymerization starting from dilactide... see e.g. "Current Progress on Bio-based Polymers and Their Future Trends By SpecialChem - August 8th, 2013"
Best regards and Happy 2015, Joachim
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