Earlier research on coumarin showed very promising results, but some of the in vivo studies using rodents showed toxicity, which was discovered to be a metabolic pathway that is not usual in humans. But the compound was taken off the market in a number of countries, which is a real shame since it is one of the few and only pharmacological approaches that has shown success in reducing protein accumulation. If you are doing research in this area, please contact me.
Thanks,
Elaine Weil, NP
Due to the reduced stereo-electronic effects of the chlorine atoms and the interaction of the pie electrons of the alkyne and the alkene, the alkyne should be more stable towards Diels-Alder reaction than the cis-alkene. Furthermore the product formed from the alkyne and alkene would be less stable (more strained 120 v 90) the one formed from alkene and and another alkene (108 v 90).
Mostly these type of compounds exhibit good results in-vivo studies but prolong use leads to side effects.
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