The old overload theory by Morrow (1988) has been given new light by the work of Jurgen Pauluhn. Is anybody aware on recent reviews putting volumetric loading versus surface area as a metric?
As it happens Paul Morrow died a few weeks before I put the question on this forum. Particle & Fibre Toxicology (PFT) T will try to bring tribute to his work by a review on this topic. Keep on eye on www.particleandfibretoxicology.com
which type of risk are you talking about ? I understand some work has been done on interacting particle systems filters applied to credit risk, but is this your intended topic ? or is it health hazard ?
The German MAK Commission has published in 2012 a document on Granular Biopersistent Particles using the various approaches approaches associated with lung overload and, ECETOC has just completed a Task Force Report on Lung Overload. This will be published shortly I believe. It also addresses these issues