I have been researching this for a while now. There are literally over 500 chemicals from plants that have or are being studied as antiviral agents for COVID-19. That is also the number that have been proven, in vitro, to be antiviral, including the coronavirus. Most of them are probably more useful prophylactically than for treatment, but there has been no absolute proof of in-vivo therapeutic effects by the ultimate Double-blind Placebo controlled study yet. Some of the most promising ones included quinine and resveratrol, as examples. As they say, much more research is required on the subject. Thank you and stay safe in the meantime. July 26, 2020, Gary Ordog, MD
I have been researching this for a while now. There are literally over 500 chemicals from plants that have or are being studied as antiviral agents for COVID-19. That is also the number that have been proven, in vitro, to be antiviral, including the coronavirus. Most of them are probably more useful prophylactically than for treatment, but there has been no absolute proof of in-vivo therapeutic effects by the ultimate Double-blind Placebo controlled study yet. Some of the most promising ones included quinine and resveratrol, as examples. As they say, much more research is required on the subject. Thank you and stay safe in the meantime. July 26, 2020, Gary Ordog, MD
Dr. Das: I just noticed that you are from India, so I should mention one of the candidates is "black tea" and probably one or all of the n-methylxanthines, maybe theophylline, is antiviral; probably prophylactic and mildly therapeutic. It is also a good bronchodilator as you are probably well aware. Again, thank you and stay safe.
There is still need more research on it. Because there are many medicinal herbs that have some beneficial effects on COVID19 but have to identify the medicinal plants which are more effective and their phytoconstituents. On the other hand, a combination of one more extract may be effective in the treatment but it will be difficult to identify the molecular compounds. However, the combination of isolated compounds after modification will be more reliable.
There are some remedies from herbs which may improve the lives of the present scenario:-
1. Nigella sativa seeds or Oil - can be used in cooking foods or take with warm water
2. Piper nigrum: can be used in cooking foods or take with warm water
3.peppermint: can be used in cooking foods or take with warm water
4. Eucalyptus essential oil: can be used in cooking foods or take with warm water
5. Clove or clove oil: can be used in cooking foods or take with warm water
You can use them in combination with the ratio of 1/2: 1/2: 1: 1/2:1/2 spoon (tea spoon) in 500 ml of warm water or you can use directly in your food mostly in vegetables or meat during cooking.
In India, a study has shown anti-mouse coronaviral activity (a surrogate of SARS-CoV) by the plants Indigofera tinctoria (AO), Vitex trifolia, Gymnema sylvestre, Abutilon indicum, Leucas aspera, Cassia alata, Sphaeranthus indicus, Clitoriaternatea, Clerodendruminerme Gaertn, Pergulariadaemi and Evolvulus alsinoides in Tamil Nadu (Vimalanathan et al., 2009). Among them Vitex trifolia and Sphaeranthus indicus have been found to reduce inflammatory cytokines using the NF-kB pathway, a pathway that has been implicated in respiratory distress in SARS-CoV (Alam et al., 2002; Srivastava et al., 2015). Clitoria ternatea has been identified as a metalloproteinase inhibitor, ADAM17, a metalloproteinase that is involved in ACE shredding can be targeted using this plant, as ACE-2 shredding has been associated with an increased formation of viruses (Maity et al., 2012). The plants Glycyrrhiza glabra (Nourazarian, 2015) and Allium sativum (Keyaerts et al., 2007) have been known to target the viral replication of SARS-CoV, arising as promising candidates against SARS-CoV-2. Clerodendrum inerme Gaertn, another herb has been found to have the potential to inactivate the viral ribosome, this can be further investigated for its utility as a drug targeting SARS-CoV-2 protein translation (Olivieri et al., 1996). Similarly, Strobilanthes Cusia(Tsai et al., 2020) blocked the viral RNA genome synthesis and induced papain like protease activity targeting the HCoV. In Asia, Himalayan forests are abundantly flourished with rich medicinal plant species and a study has documented the presence of ethnomedicinal plants against bronchitis (Amber et al., 2017). The study screened the antiviral plant properties against bronchitis, which showed that Hyoscyamus niger, Justicia adhatoda and Verbascum thapsus reduced infections caused by influenza viruses.
Some of the medicinal plant in Iran have an antivirus characteristics but Not approved anything on behalf of the ministry of health, care and medical education, yet.
Not yet. Most of the plants tested on covid 19 were later discovered to be antimalaria. Even the recent claim by a country (Madagascar) on the cure of covid 19 by herbal plant extract (The covid Organic) has been reputed by WHO and many countries that purchased the product in bulk.
Similarly, none of the existing plant extract is found to be active against the covid 19 virus.
Many plant extracts contain micronutrients and phytochemicals which boost immune system and help ward off viral infections, including the virus that causes Covid-19
Several plants and their secondary metabolites have been suggested to have potency against Corona virus, especially in ex vitro studies. However, there has not been any approved plant-derived drug for the virus at present.
Medicinal plants possess bioactive compounds that exhibit antiviral properties. The antiviral bioactive metabolites such as lignans, flavonoids and alkaloids obtained from the plant extracts may show effectiveness against SARS-CoV-2 after clinic trials.