While HSC's start proliferation and differentiation into specific mature immune cells, they need certain agents which will guide throughout entire pathway of differentiation. Most of the time, interleukin's play vital role in HSC to specific differentiation of immune cells. Though our investigations has revealed some of the interleukin's role but not most of them; still, it is one of the basic question of physiology to pinpoint the role of interleukin's in hematopoiesis . Can we enlist specific interleukin's role throughout the physiological hematopoiesis of the body ?