Dear Value Researchers !!!
We have been developing a new generation of miniaturized , nano-electrochemical sensor, in which the working (WE) and counter (CE) electrodes are separated by sub 100 nm. We call it nanogap based electrochemical sensor).
However, we are facing a serious issue of making a good, integrated reference electrode (RE) on our chip.
Currently, we must use the external RE. This led to cumbersome microfluidics ( for housing this external RE), and also may degrade the sensitivity of the recorded signals ( as the distance from the inserted RE to WE and CE is in the mm range, and is probably too long (While the distance from WE to CE is sub 100 nm only).
Can anyone kindly recommend a good article for solving this issue: Integration of micro RE on electrochemical chip?
Especially, if you have deep experience on the issue, please offer your advice/services. We are willing to collaborate on this issue to make the complexed nano-electrochemical sensors.
Our several crucial questions need to be addressed are:
(1) Suitable process flow to make a good, integrated, miniaturized RE;
(2) Suitable size of Miniaturized RE for the nano WE and nano CE ( we think RE must be reduced in size as well because WE and CE is really small in size now);
(3) Optimal distance from the realized RE to nano WE and nano CE.
Advice/ commercial –scientific collaboration or consulting fee are all possible; please just let us know via direct contact.
Looking forward to hearing from you.
Best regards
Hien D Tong
Hello Tong,
Are you certain that a RE is entirely necessary for your experiment? I would recommend reading the following article by Sarkar et al., the thesis is also worth reading.
http://pubmedcentralcanada.ca/pmcc/articles/PMC4465345/
I think the most practical solution at present is to create an Ag/AgCl psuedo-reference, the following articles and thesis are worth looking at, there are a few similar articles you'll find with a search. Hope it helps.
Article Fabrication of a microfluidic Ag/AgCl reference electrode an...
Article Microfabricated Reference Electrodes and Their Biosensing Applications
https://pdfs.semanticscholar.org/0efd/c7b3ee5fee8b6160c2724d8cf5a92f790e48.pdf
https://uu.diva-portal.org/smash/get/diva2:1147672/FULLTEXT01.pdf
Jules
Dear Jules
Thank you very much for your really informative information and articles.
My team will study your suggested sources carefully, then hopefully can find out the good clues to go further.
Best regards
Hien D Tong
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