In silico tools to predict cardiac Na and Ca ion channels blockers for small molecules?

Morkonda Rajaram Srinivasan @Morkonda-Srinivasan

29 January 2024 0 2K Report

Does anyone know of an online in silico prediction tool for small molecules to predict the late sodium ion channel and calcium channel of cardiac myocytes? If so, please post it here.

More Morkonda Rajaram Srinivasan's questions See All

Which MWCO filter to use to get rid of unwanted proteins?

I am working with snake venom, specifically targeting toxins around the 15 kDa range. I need to remove higher molecular weight toxins (above 20 kDa). Would it be advisable to use a 20 kDa MWCO...

05 June 2024 691 1 View

In Entity relationship (ER) diagram, How to create more than path from one entity to another entity with meaningful connection?

ER (Entity Relationship) Diagram helps to find the path path between one entity to another entity, or one attribute to another attribute. But most of the ER Diagram has only one direction to...

26 May 2024 8,662 0 View

Why is sphere not a valid crystal structure ?

If u see nature ex:- honeycomb it is made of hexagon which on heating forms a sphere but y not in crystallography?

26 May 2024 6,604 5 View

Why do sometimes O-H peak of carboxylic acid disappear in NMR spectrum?

Reason for the disappearance of O-H peak in NMR

24 April 2024 5,816 5 View

In fluorescent chemosensor, why the designing of the prob is getting difficult in different solvent environments?

24 April 2024 2,812 1 View

I prepared 8-formyl-7-hydroxy-4-methyl coumarin by duff reaction. recrystallisation of pdt with ethanol is giving sticky compound.is it pure?

It is from 7-hydroxy-4-methyl coumarin with HMTA in dil acetic acid at 90 degrees for 6 hrs and hydrolysed with 20% HCl, kept for 30 min. cooled overnight and extracted with ether.

15 April 2024 3,941 0 View

How to convert text into SQL Semantically with the consideration of tuples?

Most of the AI2SQl automatically generates SQL Query based on the training data. I want to generate a Query with the consideration of the Values present inside the table. Suppose a value called...

08 April 2024 5,731 3 View

Endogeneity Analysis without the access of raw data?

I currently have the correlation/covariance matrix for a set of variables, as well as the output from a regression analysis, but lack access to the underlying raw dataset. Given these...

03 March 2024 6,116 4 View

What is the recent developments in microbial fuel cell ?

In microbial fuel cell Which type of electrodes and membranes can be used and what is the material (waste) is taken.

12 February 2024 5,956 1 View

Advances in Science, Technology and Engineering Systems Journal (ASTESJ)?

Received Invitation for article extended version of my IEEE conference paper. In Advances in Science, Technology and Engineering Systems Journal (ASTESJ) What actions do you recommend?

08 November 2023 843 1 View

What precautions should be taken while handling S. aureus enterotoxin Type B in the lab?

I would like to understand potential safety concerns while handling SEB in the lab. Especially while working in animal house facility. Would like to know precautions for handling. Sigma MSDS...

07 August 2024 6,034 3 View

How to understand this crystallographic phenomenon of low temperature crystals in zeolite?

During low-temperature testing, new diffraction peaks that appear could be indicative of several phenomena. In one of our tests, we observed notable new peaks around 40° and 45° in a specific...

06 August 2024 726 3 View

What are the steps of formulating a herbal extract into a sheep/goat drench?

I am working on natural remedies for de-worming in small ruminant livestocks. Part of my project involves formulation of drench-type product, which I have not much experience in. My experience is...

30 July 2024 9,806 1 View

Do some Staphylococcus aureus strains have in vitro antimycobacterial activity ?

Some Staphylococcus aureus strains Inhibit the growth of Mycobacteria in Mueller Hinton Agar medium containing 10% OADC. Do some Staphylococcus aureus strains have in vitro antimycobacterial activity?

29 July 2024 10,023 2 View

Has the Affordable Connectivity Program Helped You/Your Community? And Would Bulk Tablets on a Similar Program Help Your Business?

Do You Believe VP Harris Would Show Empathy to Tech Companies in Her Administration as POTUS? I ask in light of the fact that, the ACP was not re-funded this round. So many and businesses need...

24 July 2024 4,732 3 View

How do we pick data for determination of Validation Acceptance Criteria?

Hello, colleagues! There is commenting open for new upcoming edition of USP 1033. Validation target acceptance criteria is now different from what it used to be and it doesn't include Cpm....

23 July 2024 7,292 3 View

When I am trying to distill triethyl amine while drying it over calcium hydride. How do I design the setup to let hydrogen escape without losing NEt3?

I am new to research. The boiling point of triethyl amine (NEt3) is 89 degrees centigrade. I am skeptical that when I will let the hydrogen escape which is getting generated in situ, I will also...

21 July 2024 7,284 4 View

Does anyone notice the tumor regression impact of Hepa1-6 cells in HCC orthotopic mice model?

To establish an orthotopic HCC model, C57BL/6 mice (male, 6-8 weeks) were orthotopically implanted with 3x106 Hepa1-6 cells (Over-expressed with a human gene) in 20uL Matrigel into the left lobe...

18 July 2024 9,177 2 View

Techniques regarding protein-protein interaction in vitro?

What techniques or assays will be used when a purified lyophilized powder is purchased from a company to study protein-protein interaction?

15 July 2024 1,598 3 View

How can we identify (in silico) the interacting amino acid residues or the nucleotides involved in the Protein-Protein / Protein-RNA interaction?

Hello! everyone, I am trying to study in silico Protein-Protein and Protein-RNA interactions. Now, is there any tool with which I can identify the interacting amino acid residues or the...

14 July 2024 950 2 View