Does it even make sense to study other outcomes in a matched nested case-control study? In these type of studies, do we always have to use case /control as our outcome?
You can only study one outcome "caseness" ie the condition that defines a case.
you can however study any number of risk factors and their relative distributions in the cases and non cases (referents or controls) will determine OR s for these risk factors.
By matching on confounding factors you can not study ORs for these confounders.
If you have matched for that variable then you can't study. Second is that you can consider the risk factors in context of outcome (Case/control) not between independent variables of cases and control...the study is not designed for that
no you cannot do that. In case of case-control study your outcome will be binary that is diseased and nondiseased. Plus the variable you are matching on cannot be studies.
Nested case control study must be a sub-design in another study design say "cohort study" in cohort studies you may measure more than one outcome. This means that you can make more than one nested case-control study .In each one you identify risk factors for a given outcome.
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