This link may be useful

https://www.ncbi.nlm.nih.gov/m/pubmed/25782017/

regards

Dear Khalid, thank you for your quick response!

To be more precise, because of a contraceptive that inhibits FSH and LH synthesis and liberation, a consequence would be an initial ceasing of testosterone (T) production, hence, a lowering of the plasma T concentration. We identified that the chronic physio-pathological effect is the formation of a "compensatory" hyperplasia of Leydig cells. Latest hormone analysis shows an elevated T concentration, which seems plausible but unlikely, as no FSH and LH is present to promote testosterone synthesis. Wondering if there are other testicular (Sertoli cell, etc.) co-factors that have a hand in it, other than extra-testicular sex-steroid synthesis?

Cheers,

Dear Derek,

I know that this may sound like a truism but the mechanism You mentioned - may be similar in the aetiology of leydigioma, where Leydig cell hiperplasia develops. So I suggest to follow this path in search of an answer to Your question.

Best,

Marcin

Dear Marcin,

Thanks for taking the time to respond.

Appreciate your feedback!