As we published in article The prospective register of acute decompensated heart failure: an experience of one center mean GFR on time of hospitalization was 63 ml/min, GFR below 60 ml was in 46% and increase up to 53% during hospital stay.
What do you think if it possible to use sorbents in those patients?
For examples - we use patiromer or similar sorbents in patients with hyperkaliemia...
http://www.umj.com.ua/wp/wp-content/uploads/archive/72/pdf/1475_rus.pdf?upload=
Little data known about sorbents in HF.
For example: Evaluation of Cross-Linked Polyelectrolyte (CLP) With Placebo in Heart Failure Subjects (STEPWISE).
"CLP-1001 has shown great promise in alleviating the negative impact of fluid overload in heart failure patients as demonstrated in our prior Phase 2a clinical trial. We look forward to reporting data from the STEPWISE trial later this year," said Detlef Albrecht, M.D., Sorbent's President and Chief Executive Officer. "I would like to thank our existing investors for their continued support. This new round of funding and the progress in our lead CLP program take us several steps closer to achieving our goal of bringing a new therapeutic option to advanced congestive heart failure patients."
I have little experience in clinical trials. Results published in N Engl J Med.
CONCLUSIONS
In patients with chronic kidney disease who were receiving RAAS inhibitors and who had hyperkalemia, patiromer treatment was associated with a decrease in serum potassium levels and, as compared with placebo, a reduction in the recurrence of hyperkalemia.
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