it is right to say that the THP-1 cells come from young boy and he is dead now but his cells still alive and widely use in medical research? this question is theory ?
THP-1 is an established cell line. Therefore, ethical concerns associated with establishment of primary culture is not necessary.
However, you need to follow all due guidelines for acquiring, maintenance and genetic modifications of rxisting cell lines. Following article will cover almost everything you need to know
http://www.nature.com/bjc/journal/v111/n6/full/bjc2014166a.html
Interesting thoughts. Thank you for sharing.
Cell lines, except those known to carry infectious agents, are generally not considered ethical concerns. In the other words, the concern is more on safety. They are rather like clones of selected cell products.
I agree with Dr. Mishra, cell lines are no longer primary cells. They are replicates.
While I agree with the previous two comments, it is important to also be aware that ongoing risks to the donor may apply from using cell lines. These risks relate to loss of privacy (re-identification of the donor). The more genetic information is made available and linked up, the more it is possible (at least in theory) that the donor can be identified.
If you are working with an established cell line like THP-1, the main thing to think about is whether what you publish might lead to identification of the donor. Usually this risk is very low. It is higher with cell lines like HeLa, where the donor's identity is already in the public domain and publication of genomic data may affect the donor's family.
For more information on the implications of the HeLa genome, see http://www.nih.gov/about/director/statement-hela-08072013.htm.
Hi Shoxan,
As long as the identity of the donor is not compromised, established cell lines should not raise ethical concerns. While I can understand that you are extremely cautious, please make sure that the donor identity is not revealed even in the publications. You and Amanda are very cautious and perhaps that's how we should be.
Omer
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