Structure of curcumin has beta-diketone. The mentylene active in position between the beta-diketone make more available for modification.

Other hand, the methylene active in dimedone compound so powerful for synthesis, but not success if apply to methylene active in curcurmin compound?

I think, because beta-diketone in curcumin predominant in enol form inspite keto form

How to manage the condition for predominant for keto form ?