The sequences have been copied and pasted from sequence records in NCBI GenBank into a word (text) file. I have tried many programs (Jalview, MEGA, ClustalW, Clustal Omega. They do not seem to have the capability to handle large and numerous sequences. I intend to produce a Distance matrix and a phylogenetic tree after the analysis. Kindly suggest programs that can handle such data and how to go bout this problem.