Sounds very unlikely. How many replicates do you have?

Could be that you have ~0 signal in one of the samples, which gives you enormous fold change

In my experience, when I take fold change data, usually have 2 fold, 3.........may be 100 or so, then large numbers. So I use a suitable cut-off point and then the rest is considered as present only in one sample

Thank you so much for your guidance , Alexey and Keerthi!