If you can explicitly explain what are your reactants it will be helpful.

Hello Vijay,

I am trying to synthesize chalcones from 4-(1-Acetylpiperazin-4-yl)phenol and benzaldehyde.

Dissolve your aldehyde and acetyl compounds in methanol first, reflux it. After completely dissolving the starting materials add catalytic amount of piperidine while the reaction mixture is still hot, stir vigorously till product formation.

This will help in synthesizing chalcones, if not explain the reactants in detail that you are using.

thank u

Though I have not worked on this particular ketone, I believe that proton on COCH3 is not acidic enough to be extracted by the base as it is amide type carbonyl. I would suggest you to use stronger condition. May be you can use ethoxides to generate ketone anion. 

you can prepare chalcone in glacial AcOH/AcONa and reflux it

Methanol solvent and KOH should work for your reaction as per the literature.

Synthesis and antimicrobial activity of new series of piperazine containing chalcone derivatives

PHARMANEST (2014), 5, (2), 1943-1946.

Dear Mr. Bhat, do you intend to study this reaction type or are you mainly interested in the chalcones. Cinnamic acid chlorides will give your desired "chalcone - structure" if combined with unprotected 4-piperazinylphenole. It may be that you have to find a way to protect the phenole end - but usually a Schotten Bauman procedure will give satisfactory results to get the desired amide instead of phenolesters.

Best regards, Dr. Wolfram Eichinger

thank u Dr. Wolfram Eichinger

For the synthesis of the Chalcone derivative of 4-substituted n-acetyl piperazine  you can carry out try  reaction under unhdrous condition using sodium ethoxide in ethanolunder refluxing condition.