Hi all,
I need to make stock solution of TFA(triflic acid) in dry dcm for ring opening polymerization.
Is it possible to place TFA in liquid nitrogen, and while is in liquid nitrogen vacuum the air out. After removal from liquid nitrogen add nitrogen flow and add the dry dcm inside.
Is this protocol possible or you have some better suggestion? Never did this reaction so ask for safest way to perform this procedure. Appreciat all the help.
While I agree that the freeze-pump-thaw method can be used, I would advise against it, as the boiling point of oxygen is just a bit higher than that of nitrogen (~90K for O2 in comparison with ~77K for N2), meaning that the oxygen present above your TFA will condense and contaminate it.
Frankly, I would recommend instead extensive purging the liquid TFA with dry pure nitrogen (i.e. 6.0 purity), preferrably at low temperatures, to avoid producing too much TFA vapours.
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