I have loaded 2 compounds and a nanoparticle to a cream base. I need to study the drug release of the compounds and nanoparticles individually. Please suggest me a better technique/technology for carring out timely drug release.
Drug release from an ointment/cream can be best studied by using the technique of "Franz-cell diffusion set-up", which is an efficient and easy method to be followed. For detailed procedure, please refer to following research articles:
1) doi:10.4103/2229-5186.94311
2) doi:10.3390/pharmaceutics2020209
Hello.
I agree that Franz cells are a likely option. However, make sure you select a membrane that is highly permeable and not rate-controlling, such as a high MW cutoff cellulose. Also, make sure the receiver medium maintains sink conditions but does not interact with and alter the ointment formulation.
There are some other methods for ointments as well that you may consider, such as USP 2 and 4 with adapters. (See doi: 10.1016/j.jconrel.2018.03.003)
Good luck!
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