I am having many singleton Species (species representing only one DNA sequence). These singletons lack resolution potential as they are single, when applied machine learning classifiers singletons are not considered as there is no reference for it... Even using other relevant methods, we cannot resolve singleton species confidently.
Please suggest any method/program that could simulate or generate reference sequences by taking those singletone species into consideration. Further this reference sequence could be used to resolve singleton species in the multiple species sequence dataset.
There might be ways to do that, but I wonder why do you need to classify the singletons?
Singletons are the sequences just present one and most probably are orphan sequences generated by sequencing error. Therefore they are discarded.
Abhijeet Singh Kindly read carefully about my question, in bracket I have mentioned that these are singleton species with only one individual sequenced and not just singletons that you misunderstood those to sequences generated by sequencing errors.
I have read the question carefully and what you have wrote in brackets does not mean singleton species.
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