How to remove xylene from reaction mixture?
I have prepared acetamide using xylene, I meed to remove xylene from the reaction mixture. Can I distill it or any other simple methods available for removal of xylene.
Dear Chitturi bhujanga rao,
Xylene: boiling point = 138.4 C
Solubility; insoluble in water; soluble in aromatic hydrocarbons and very soluble in ethanol and ether.
Acetamide: boiling point = 221.2 C
Solubility: ethanol 500 g L−1
pyridine 166.67 g L−1
soluble in chloroform, glycerol, benzene
According to this data, you have two methods for the removal of xylene:
1-By distillation; xylene will be distilled first at 138.4 C, whereas acetamide will be distilled at 221.2 C.
2-By solubilization; acetamide is soluble in water, whereas xylene is insoluble in water. Therefore, add sufficient amount of water to the reaction mixture, separate the two phases. Transfer the aqueous phase to a round bottom flask, evaporate the water to dryness. Dissolve the residue in ethanol, dry over MgSO4 anhydrous, filter and evaporate to dryness. The residue will be pure acetamide.
Hoping this will be helpful,
Rafik
Dear Chitturi bhujanga rao,
anhydrous cacl2 also useful.
www.worldofchemicals.com/.../xylene-a-solvent-mixture-of-three-isome.
home.ust.hk/~rtong/Organic%20Reaction%20Workup.pdf
www.mdpi.com/1660-4601/12/2/1334/pdf
https://books.google.co.in/books?isbn=1461442591
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