During the formation of dipyrromethane, there remains unreacted pyrrole,which I am not able to remove through vaccum.it later creates problems in seperating the desired compound through column chromatography.please provide a better suggestion.
Please look at the following below the attached papers which may help you in your analysis.
Thanks
Use Column Chromatography (Hexane/ethyl acetate = 4/1 solvent system), using this solvent pyrrole elutes first, followed slowly by the dipyrromethane (the target compound), and followed later by tailing materials. Finally please use 100% hexane to wash slowly and repeatedly. Please read this article carefully and follow the techniques applied here; Tetrahedron Vol. 50, No. 39, pp. 11427-11440,1994 (this is an old and still very important article which is published by professor Change Hee Lee)
Thanks for the suggestion.but please let me know how can we run every column in 4/1 hexane: ethyl acetate.It will depend upon the polarity of my compound
You can try using activated carbon sorption at a lower temperature. Pyrrole is well sorbed on activated carbon. Use dichloromethane as solvent.
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