Dear RG colleagues,
Looking for the "green perspective", we are developing the microencapsulation of additives (volatile oils, active pharmaceutical ingredients (API), etc.) in microcapsules of biopolyesters such as PLGA, PLA, others., using adapted emulsion-evaporation techniques. However, as it is mentioned in the State of the Art, the sticking of microcapsules in the process of removing of solvents is very frequent. Based on your practical experience, could you provide an advice to reduce the aggregation of microcapsules? Thank you for your input and best regards!
Dear Neha,
Firstly, many thanks for the information about the biopolymers commercialized by your company.
I have noted also your recommendation to try to use a Zn derivative in the idea to end-cap the carboxyl end groups of PLA or PLGA, with effects in reducing the aggregation of microcapsules during evaporation of solvents. However, if you have some practical examples or additional information from literature, don’t hesitate to share with me.
Many thanks and best regards,
Marius
You can try to increase the hydrophilicity and Zeta potential of the outer surface of microcapsule. And reducing the size of microcapsule and the ion strength of solution is also helpful.
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