Hi! I`ve got question about DESs. How can I proof the formation of DES? If speak about IR, which regions should I look at and which bands can indicate on the presence of hydrogen bonds? And one more question: the addition of water results full distruction of DES or water will only dilute DES? Is there any information about how much water I can add to the DES before it stop being DES and become "water and dissolved substances"?
Dear Arina Levina thank you for your interesting technical question. The question would certainly get more qualified answers if you explained what you mean by DES. I had a hard time finding it out. When you check the Wikipedia entry on the abbreviation DES you find no less than 26 different meanings of DES on the English page, from "Data Encryption standard" to "Deep Eutectic Solvent" (https://en.wikipedia.org/wiki/DES).
Since you were talking about hydrogen bonds in your original question I assume that in your case DES stands for desloratadine, right? Just in case that this is still of interest to you:
In this context, please have a look e.g. at the following useful link which is freely available as public full text:
Improving mechanical properties of desloratadine via multicomponent crystal formation
Article Improving mechanical properties of desloratadine via multico...
For the stability of desloratadine in water, please also see the following relevant article:
Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media
Article Acid-base equilibria and solubility of loratadine and deslor...
It could also pay off to use the "Search" function of RG to find and access other useful references on this topic. Just search for "desloratadine" and then click on "Publications". This will result in a large number of interesting articles:
https://www.researchgate.net/search.Search.html?type=publication&query=desloratadine
Good luck with your work and please stay safe and healthy! 😊
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