Poultry diseases cause increased mortality and high economic losses. Is it possible to breed to produce disease-resistant poultry strains?
It would be very long and expensive, but not impossible. To achieve this, chicken breeds with a high genetic variability would be required, since many of the current breeds have been improved for productive characteristics, which has caused that the current chickens are more susceptible to some diseases, which has caused a low heritability of the characteristics related to resistance to diseases. Therefore, it is necessary to increase the genetic variability to obtain individuals with high genetic heritability to specific diseases.
The high rate of virus mutation of the influence would bring a high variability of the proteins that compose it, which would bring a large amount of RNA. With the complete characterization of all the proteins one could obtain RNA and subsequent DNA, thus you can trace this DNA fragment in some individuals
It is a long process to develop disease strains through systematic genetic breeding by keeping proper records. If family status is properly recorded (fullsib/halfsib mating), one can possibly identify families which are resistant/susceptible for the disease. Then, resistant families/individuals are selected for future mating and reproduction, disease prevalence studied, such that families with relevant pedigree records are maintained to plan future mating to develop disease resistant varieties. Such developed varieties/individuals are exposed to the disease environment to study their resistance in challenging conditions. This is a long drawn out process, but useful in the long run.
2. The resistant varieties can be alternatively genetically mapped to identify the locus responsible for the disease.
lnathgubbi
Thanks for all Md Zulfekar Ali Loknath G.R.
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Poultry diseases cause increased mortality and high economic losses. Is it possible to breed to produce disease-resistant poultry strains by increasing the immunity of broiler
May be you find the following papers useful:
https://www.frontiersin.org/articles/10.3389/fmicb.2019.01432/full
https://www.nature.com/articles/s41598-021-89464-1
Vertical diseases can be controlled thro' gene mapping, of the family and determining the nature of genetic control and inheritance. Planned breeding methodology will help developing resistant strains. It should.be done in isolated and controlled houses to prevent the possible chances of spreading the infection to unaffected flocks.
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