The relationship between the dose and the plasma concentration/ or effect of a drug is completely different form adult to neonates and pediatrics. Most of the doses used today in pediatrics and neonates should be checked regularly for accuracy and to obtain maximum effect and reduce the side effects. For this purpus TDM is very essential for every drug especially those which have narrow therapeutic index...Phenytoin, Carbamazepine......
BUT, the problem now how can we obtain the most recent (updated TDM for each drug) and it should be accurate (is there is any official source in 2018 we can depend on it for TDM in pediatric and Neonates)
The relationship between the dose and the plasma concentration/ or effect of a drug is completely different form adult to neonates and pediatrics. most of the doses used today in pediatrics and neonates should be checked regularly for accuracy and to obtain maximum effect and reduce the side effects.
we have some papers on TDM in neonates if people were interested in the background and the issues of TDM in neonates, uploaded in the website and pdf available.
Therapeutic Drug Monitoring in Neonates: What Makes them Unique?
Mian P, Flint RB, Tibboel D, van den Anker JN, Allegaert K, Koch BCP.
Curr Pharm Des. 2017;23(38):5790-5800.
Therapeutic drug monitoring in neonates.
Pauwels S, Allegaert K.
Arch Dis Child. 2016 Apr;101(4):377-81
We had studied the side effect through ABR in thesis since 8 years .
recently this article may help
Vancomycin therapeutic drug monitoring and population .
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113434/by JF Monteiro - 2018Aug 28, 2018 -
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