In an ionic solution a charged surface also attracts counterions from the solution, forming an electrical double layer (EDL). This EDL effectively screens off the charge, and in physiologically relevant conditions, the characteristic charge screening length (Debye length) is less than a nanometer (nm). Thus, in high ionic strength solutions, charge based (DC) detection is fundamentally impeded. What are established solutions to overcome this problem?
Anne Sawhney
Yes - don't use DC detection. I assume your target is also charged. Try using EIS, with double-layer capacity as the variable of interest, since it will be ultra-sensitive to the concentration of charged species.
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