I am working on synthesis of polar ligand using chloro acetate as one of the reactant. But chloro acetate doesn't appear on TLC under UV light. How to observe that chloro acetate has been completely reacted?
Generally speaking, chloroacetates are either ionic or highly polar compounds. Such compounds are difficult to identify by TLC simply because they will hardly move from the baseline on the TLC plate.
Chloroacetates can be detected well by NMR or the simpler IR spectroscopy. The C-Cl frequency in an IR spectrum appears strongly at 600-800 cm-1 . This 52 pages pdf file can help in characterizing other functional groups in these compounds:
http://chemistry.syr.edu/totah/che575/support/3a1/2-2.IR.pdf
Thank you Dr. Nizar Matar . I used TLC to monitor and determine when I should stop the reaction. Is there any faster method I can use to monitor chloroacetates? Analysis using NMR can take time.
Use capillary elfo. It should be available in the analítical department(s). Within 10-15 minutes, including the walking, you can get the result. And that can be made to be more quantitative than IR or TLC.
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