I am trying to use CB(8) and various gels as a part of my PhD project, and wish to do some NMR on it to confirm inclusion within it. But as it is quite insoluble in many solvents or they become a gel in other solvents, I do not know the best way to go about it. Any suggestions would be appreciated!
What feature the spectra and, or methods can you use to confirm inclusion?
The rate of overall molecular motion determines how much H-H dipolar coupling contributes to the H--1 and/or C-13 NMR line widths.
For solids, you would need to use solid-state NMR methods.
For gels, the answer depends on the viscosity of the sample. H-1 NMR may be possible. The lower the viscosity the more narrow the line widths. If the inclusion complexes are stable above room temperature, increasing the probe temperature could be helpful.
Finally, is there a dynamic equilibrium between inclusion and non-inclusion species? If you are unlucky, the exchange rate could render the relevant lindwidths to be very broad.
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