I want to do bromination of benzimidazole by NBS kindly suggest me workup process to remove succinimide after complition of reaction?
add DCM or E.A to your reaction mixture and washed it with saturated NaHCO3, H2O and finally with brine.
add a organic solvent like dichloromethane or ethyl acetate, quench with Sodium bicarbonate solution, wash with sodium thiosulphate solution and finally with brine.
The above suggestions are excellent. In addition, doing the reaction in CHCl3 will cause most of the succinimide to precipitate, allowing simple filtration. Traditionally these reactions were conducted in tetrachloromethane, however it's use is now restricted for environmental and safety reasons.
Using triethylamine instead of Sodium bicarbonate solution, is also good method
Dear friend,
NBS bromination reaction , don't work up, after complete reaction add slowly ice water will form white precipitate. after filtration will get good yield, above 95 %
Bromination of benzimidazole by NBS . Use solvent NBS and CCl4 as solvent.It is radical reaction. After the reaction is over , treat reaction mixture with water so that succinimide formed becomes soluble in water . then the remove CCl4 layer and evaporate under reduced pressure to get a bromo compd.
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