If you are going to model it you will need to include the near-field region. Conductive or dielectric loss in the near electric field will be significant.
If you want to find out about how small antennas behave, read about Electrically Small Antennas, and particularly Wheeler, and Chu.
In air best efficiency is with magnetic materials in the antenna, but this may not be so when the outside is surrounded by lossy dielectric (tissue) so it may be best to have all the electrical energy stored for example in a capacitor in the antenna which may keep the electric fields in the near-field lower.
Thanks sir for your quick reply. I appreciate your answer. Can you please calculate radiation box dimensions if we are using PDMS biocompatible material with permittivity =2.7, thickness =0.2 mm and loss tangent =0.02